CRF acts in the midbrain to attenuate accumbens dopamine release to rewards but not their predictors.
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ABSTRACT:
SUBMITTER: Wanat MJ
PROVIDER: S-EPMC3609940 | biostudies-literature | 2013 Apr
REPOSITORIES: biostudies-literature
Publications
CRF acts in the midbrain to attenuate accumbens dopamine release to rewards but not their predictors.
Wanat Matthew J MJ Bonci Antonello A Phillips Paul E M PE
Nature neuroscience 20130217 4
Stressors affect dopamine-dependent behaviors such as motivation, although the underlying neurobiological mechanism is not well defined. We report that corticotropin-releasing factor (CRF) acts in the ventral tegmental area (VTA) to reduce the motivation to work for food rewards. CRF in the VTA regulates dopamine output in a stimulus- and pathway-specific manner, offering a mechanism by which acute stress selectively regulates information transmission via the VTA to reprioritize motivated behavi ...[more]
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