Translational research in Huntington's disease: opening up for disease modifying treatment.
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ABSTRACT:
SUBMITTER: Burgunder JM
PROVIDER: S-EPMC3610231 | biostudies-literature | 2013 Jan
REPOSITORIES: biostudies-literature
Publications
Translational research in Huntington's disease: opening up for disease modifying treatment.
Translational neurodegeneration 20130125 1
Research on the molecular mechanisms involved in Huntington's disease, a monogenic disorder with a complex phenotype including motor, behaviour, and cognitive impairments, is advancing at a rapid path. Knowledge on several of the multimodal pathways has now lead to the establishment of rational strategies to prepare trials of several compounds in affected people. Furthermore, improved understanding of the phenotype and on ways of assessing it, as well as the process of developing biomarkers, all ...[more]
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