Ontology highlight
ABSTRACT:
SUBMITTER: Mehlotra RK
PROVIDER: S-EPMC3610425 | biostudies-literature | 2012
REPOSITORIES: biostudies-literature
Journal of AIDS & clinical research 20120101 10
<h4>Study background</h4><i>DEFB4/103A</i> encoding β-defensin 2 and 3, respectively, inhibit CXCR4-tropic (X4) viruses in vitro. We determined whether <i>DEFB4/103A</i> Copy Number Variation (CNV) influences time-to-X4 and time-to-AIDS outcomes.<h4>Methods</h4>We utilized samples from a previously published Multicenter AIDS Cohort Study (MACS), which provides longitudinal account of viral tropism in relation to the full spectrum of rates of disease progression. Using traditional models for time ...[more]