Ontology highlight
ABSTRACT:
SUBMITTER: Wang C
PROVIDER: S-EPMC3610540 | biostudies-literature | 2012 Jul
REPOSITORIES: biostudies-literature
Wang Chaojian C Chung Ben C BC Yan Haidun H Lee Seok-Yong SY Pitt Geoffrey S GS
Structure (London, England : 1993) 20120614 7
Voltage-gated Na⁺ (Na(V)) channels initiate neuronal action potentials. Na(V) channels are composed of a transmembrane domain responsible for voltage-dependent Na⁺ conduction and a cytosolic C-terminal domain (CTD) that regulates channel function through interactions with many auxiliary proteins, including fibroblast growth factor homologous factors (FHFs) and calmodulin (CaM). Most ion channel structural studies have focused on mechanisms of permeation and voltage-dependent gating but less is k ...[more]