Ontology highlight
ABSTRACT:
SUBMITTER: Yamashita AS
PROVIDER: S-EPMC3610552 | biostudies-literature | 2013 Apr
REPOSITORIES: biostudies-literature
Yamashita Alex Shimura AS Geraldo Murilo Vieira MV Fuziwara Cesar Seigi CS Kulcsar Marco Aurélio Vamondes MA Friguglietti Celso Ubirajara Moretto CU da Costa Ricardo Borges RB Baia Gilson Soares GS Kimura Edna Teruko ET
Translational oncology 20130401 2
Mutually exclusive genetic alterations in the RET, RAS, or BRAF genes, which result in constitutively active mitogen-activated protein kinase (MAPK) signaling, are present in about 70% of papillary thyroid carcinomas (PTCs). However, the effect of MAPK activation on other signaling pathways involved in oncogenic transformation, such as Notch, remains unclear. In this study, we tested the hypothesis that the MAPK pathway regulates Notch signaling and that Notch signaling plays a role in PTC cell ...[more]