Development and evolution of the human neocortex.
Ontology highlight
ABSTRACT:
SUBMITTER: Lui JH
PROVIDER: S-EPMC3610574 | biostudies-literature | 2011 Jul
REPOSITORIES: biostudies-literature
Publications
Development and evolution of the human neocortex.
Lui Jan H JH Hansen David V DV Kriegstein Arnold R AR
Cell 20110701 1
The size and surface area of the mammalian brain are thought to be critical determinants of intellectual ability. Recent studies show that development of the gyrated human neocortex involves a lineage of neural stem and transit-amplifying cells that forms the outer subventricular zone (OSVZ), a proliferative region outside the ventricular epithelium. We discuss how proliferation of cells within the OSVZ expands the neocortex by increasing neuron number and modifying the trajectory of migrating n ...[more]
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