Dataset Information

Case-control studies on the relationship between onchocerciasis and epilepsy: systematic review and meta-analysis.

ABSTRACT:

Objective

A systematic review and meta-analysis of all available case-control studies on the relationship between onchocerciasis and epilepsy. Because age and level of onchocerciasis endemicity in the area of residence are major determinants for infection, an additional analysis was performed, restricted to studies achieving control of these confounding factors.

Data sources

Medical databases, the "African Neurology Database, Institute of Neuroepidemiology and Tropical Neurology, Limoges," reference lists of relevant articles, commercial search engines, up to May 2012.

Methods

We searched for studies examining infection status with Onchocerca volvulus in persons with epilepsy (PWE) and without epilepsy (PWOE) providing data suitable for the calculation of pooled odds ratios (ORp) and/or standardized mean differences (SMD) using random-effects models.

Results

Eleven studies providing data of qualitative skin biopsies for diagnosis of onchocerciasis were identified. Combined analysis on the total sample of 876 PWE and 4712 PWOE resulted in an ORp of 2.49 (95% confidence interval (95%CI): 1.61-3.86, p<0.001). When this analysis was restricted to those studies achieving control for age, residence and sex (367 PWE, 624 PWOE), an ORp of 1.29 (95% CI: 0.93-1.79; p?=?0.139) was found. Presence of nodules for diagnosis of onchocerciasis was analyzed in four studies (225 PWE, 189 PWOE; ORp 1.74; 95%CI: 0.94-3.20; p<0.076), including two studies of the restricted analysis (106 PWE, 106 PWOE; ORp 2.81; 95%CI: 1.57-5.00; p<0.001). One study examined quantitative microfilariae counts in patients without preceding microfilaricidal treatment and demonstrated significantly higher counts in PWE than in PWOE.

Interpretation

Our results strengthen the hypothesis that, in onchocerciasis foci, epilepsy and infection with O. volvulus are associated. Analysis of indicators giving information on infection intensity, namely nodule palpation and quantitative microfilaria count in untreated patients, support the hypothesis that intensity of infection with O. volvulus is involved in the etiology of epilepsy.

SUBMITTER: Kaiser C

PROVIDER: S-EPMC3610636 | biostudies-literature | 2013

REPOSITORIES: biostudies-literature

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Publications

Case-control studies on the relationship between onchocerciasis and epilepsy: systematic review and meta-analysis.

Kaiser Christoph C Pion Sébastien D S SD Boussinesq Michel M

PLoS neglected tropical diseases 20130328 3

<h4>Objective</h4>A systematic review and meta-analysis of all available case-control studies on the relationship between onchocerciasis and epilepsy. Because age and level of onchocerciasis endemicity in the area of residence are major determinants for infection, an additional analysis was performed, restricted to studies achieving control of these confounding factors.<h4>Data sources</h4>Medical databases, the "African Neurology Database, Institute of Neuroepidemiology and Tropical Neurology, ...[more]

PMID: 23556028

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Project description:BACKGROUND:The X-ray repair cross-complementing group 3 (XRCC3) is an efficient component of homologous recombination and is required for the preservation of chromosomal integrity in mammalian cells. The association between Thr241Met single-nucleotide polymorphism (SNP) in this gene and susceptibility to breast cancer has been assessed in several studies. Yet, reports are controversial. The present meta-analysis has been designed to identify whether this SNP is associated with susceptibility to breast cancer. METHODS:We performed a systematic review and meta-analysis for retrieving the case-control studies on the associations between T241?M SNP and the risk of breast cancer. Crude odds ratios (ORs) and 95% confidence intervals (CIs) were calculated to verify the association in dominant, recessive, and homozygote inheritance models. RESULTS:We included 55 studies containing 30,966 sporadic breast cancer cases, 1174 familial breast cancer cases and 32,890 controls in the meta-analysis. In crude analyses, no association was detected between the mentioned SNP and breast cancer risk in recessive, homozygote or dominant models. However, ethnic based analysis showed that in sporadic breast cancer, the SNP was associated with breast cancer risk in Arab populations in homozygous (OR (95% CI)?=?3.649 (2.029-6.563), p?=?0.0001) and recessive models (OR (95% CI)?=?4.092 (1.806-9.271), p?=?0.001). The association was significant in Asian population in dominant model (OR (95% CI)?=?1.296, p?=?0.029). However, the associations was significant in familial breast cancer in mixed ethnic-based subgroup in homozygote and recessive models (OR (95% CI)?=?0.451 (0.309-0.659), p?=?0.0001, OR (95% CI)?=?0.462 (0.298-0.716), p?=?0.001 respectively). CONCLUSIONS:Taken together, our results in a large sample of both sporadic and familial cases of breast cancer showed insignificant role of Thr241Met in the pathogenesis of this type of malignancy. Such results were more conclusive in sporadic cases. In familial cases, future studies are needed to verify our results.

Dataset Information

Case-control studies on the relationship between onchocerciasis and epilepsy: systematic review and meta-analysis.

Objective

Data sources

Methods

Results

Interpretation

Publications

Case-control studies on the relationship between onchocerciasis and epilepsy: systematic review and meta-analysis.

Similar Datasets

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