Digoxin suppresses HIV-1 replication by altering viral RNA processing.
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ABSTRACT:
SUBMITTER: Wong RW
PROVIDER: S-EPMC3610647 | biostudies-literature | 2013 Mar
REPOSITORIES: biostudies-literature
Publications
Digoxin suppresses HIV-1 replication by altering viral RNA processing.
Wong Raymond W RW Balachandran Ahalya A Ostrowski Mario A MA Cochrane Alan A
PLoS pathogens 20130328 3
To develop new approaches to control HIV-1 replication, we examined the capacity of recently described small molecular modulators of RNA splicing for their effects on viral RNA metabolism. Of the drugs tested, digoxin was found to induce a dramatic inhibition of HIV-1 structural protein synthesis, a response due, in part, to reduced accumulation of the corresponding viral mRNAs. In addition, digoxin altered viral RNA splice site use, resulting in loss of the essential viral factor Rev. Digoxin i ...[more]
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