Ontology highlight
ABSTRACT:
SUBMITTER: Yenjerla M
PROVIDER: S-EPMC3610731 | biostudies-literature | 2013 Mar
REPOSITORIES: biostudies-literature
Yenjerla Mythili M Panopoulos Andreas A Reynaud Caroline C Fotedar Rati R Margolis Robert L RL
Cell cycle (Georgetown, Tex.) 20130206 5
We previously identified TD-60 (RCC2) as a mitotic centromere-associated protein that is necessary for proper completion of mitosis. We now report that TD-60 is an essential regulator of cell cycle progression during interphase. siRNA suppression blocks progression of mammalian G₁/S phase cells and progression of G₂ cells into mitosis. Prolonged arrest occurs both in non-transformed cells and in transformed cells lacking functional p53. TD-60 associates with Rac1 and Arf6 and has recently been d ...[more]