Ontology highlight
ABSTRACT:
SUBMITTER: Miura K
PROVIDER: S-EPMC3610890 | biostudies-literature | 2013
REPOSITORIES: biostudies-literature
Miura Kazutoyo K Diakite Mahamadou M Diouf Ababacar A Doumbia Saibou S Konate Drissa D Keita Abdoul S AS Moretz Samuel E SE Tullo Gregory G Zhou Hong H Lopera-Mesa Tatiana M TM Anderson Jennifer M JM Fairhurst Rick M RM Long Carole A CA
PloS one 20130328 3
Heterozygous hemoglobin (Hb) AS (sickle-cell trait) and HbAC are hypothesized to protect against Plasmodium falciparum malaria in part by enhancing naturally-acquired immunity to this disease. To investigate this hypothesis, we compared antibody levels to four merozoite antigens from the P. falciparum 3D7 clone (apical membrane antigen 1, AMA1-3D7; merozoite surface protein 1, MSP1-3D7; 175 kDa erythrocyte-binding antigen, EBA175-3D7; and merozoite surface protein 2, MSP2-3D7) in a cohort of 103 ...[more]