Pharmacogenetic association with early response to intravitreal ranibizumab for age-related macular degeneration in a Korean population.

ABSTRACT:

Purpose

To determine whether genetic factors that influence age-related macular degeneration (AMD) have an early pharmacogenetic effect on treating exudative AMD with ranibizumab in a Korean population.

Methods

A retrospective study of 102 patients (70 with typical neovascular AMD and 32 with polypoidal choroidal vasculopathy) with exudative AMD treated with intravitreal ranibizumab monotherapy was conducted. Optical coherence tomography, fluorescein, and indocyanine green angiography were taken at the baseline. The best-corrected visual acuity (BCVA) and the central subfield macular thickness (CSMT) were recorded at the baseline and at each monthly visit. The genotypes of the polymorphisms in the known AMD susceptibility loci (CFH, AMRS2, HTRA1, VEGFA, and KDR) were determi

SUBMITTER: Chang W 

PROVIDER: S-EPMC3611944 | biostudies-literature | 2013

REPOSITORIES: biostudies-literature