Manufacturing mesenchymal stromal cells for phase I clinical trials.
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ABSTRACT:
SUBMITTER: Hanley PJ
PROVIDER: S-EPMC3611961 | biostudies-literature | 2013 Apr
REPOSITORIES: biostudies-literature
Publications
Manufacturing mesenchymal stromal cells for phase I clinical trials.
Hanley Patrick J PJ Mei Zhuyong Z da Graca Cabreira-Hansen Maria M Klis Mariola M Li Wei W Zhao Yali Y Durett April G AG Zheng Xingwu X Wang Yongping Y Gee Adrian P AP Horwitz Edwin M EM
Cytotherapy 20130401 4
Mesenchymal stromal cells (MSCs) are multipotent progenitor cells capable of differentiating into adipocytes, osteoblasts and chondroblasts as well as secreting a vast array of soluble mediators. This potentially makes MSCs important mediators of a variety of therapeutic applications. They are actively under evaluation for immunomodulatory purposes such as graft-versus-host disease and Crohn's disease as well as regenerative applications such as stroke and congestive heart failure. We report our ...[more]
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