Novel locus including FGF21 is associated with dietary macronutrient intake.
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ABSTRACT:
SUBMITTER: Chu AY
PROVIDER: S-EPMC3612009 | biostudies-literature | 2013 May
REPOSITORIES: biostudies-literature
Publications
Novel locus including FGF21 is associated with dietary macronutrient intake.
Chu Audrey Y AY Workalemahu Tsegaselassie T Paynter Nina P NP Rose Lynda M LM Giulianini Franco F Tanaka Toshiko T Ngwa Julius S JS Qi Qibin Q Curhan Gary C GC Rimm Eric B EB Hunter David J DJ Pasquale Louis R LR Ridker Paul M PM Hu Frank B FB Chasman Daniel I DI Qi Lu L
Human molecular genetics 20130130 9
Dietary intake of macronutrients (carbohydrate, protein, and fat) has been associated with risk of chronic conditions such as obesity and diabetes. Family studies have reported a moderate contribution of genetics to variation in macronutrient intake. In a genome-wide meta-analysis of a population-based discovery cohort (n = 33 533), rs838133 in FGF21 (19q13.33), rs197273 near TRAF family member-associated NF-kappa-B activator (TANK) (2p24.2), and rs10163409 in FTO (16q12.2) were among the top as ...[more]
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