Ontology highlight
ABSTRACT:
SUBMITTER: Mao B
PROVIDER: S-EPMC3612016 | biostudies-literature | 2011 Jun
REPOSITORIES: biostudies-literature
Mao Binchen B Guan Rongjin R Montelione Gaetano T GT
Structure (London, England : 1993) 20110601 6
Molecular replacement (MR) is widely used for addressing the phase problem in X-ray crystallography. Historically, crystallographers have had limited success using NMR structures as MR search models. Here, we report a comprehensive investigation of the utility of protein NMR ensembles as MR search models, using data for 25 pairs of X-ray and NMR structures solved and refined using modern NMR methods. Starting from NMR ensembles prepared by an improved protocol, FindCore, correct MR solutions wer ...[more]