Ontology highlight
ABSTRACT:
SUBMITTER: Huang TC
PROVIDER: S-EPMC3612551 | biostudies-literature | 2012 Apr
REPOSITORIES: biostudies-literature
Huang Tai-Chung TC Sahasrabuddhe Nandini A NA Kim Min-Sik MS Getnet Derese D Yang Yi Y Peterson Jonathan M JM Ghosh Bidyut B Chaerkady Raghothama R Leach Steven D SD Marchionni Luigi L Wong G William GW Pandey Akhilesh A
Journal of proteome research 20120228 4
Dicer is a ribonuclease whose major role is to generate mature microRNAs, although additional functions have been proposed. Deletion of Dicer leads to embryonic lethality in mice. To study the role of Dicer in adults, we generated mice in which administration of tamoxifen induces deletion of Dicer. Surprisingly, disruption of Dicer in adult mice induced lipid accumulation in the small intestine. To dissect the underlying mechanisms, we carried out miRNA, mRNA, and proteomic profiling of the smal ...[more]