Ontology highlight
ABSTRACT:
SUBMITTER: Hausser J
PROVIDER: S-EPMC3613578 | biostudies-literature | 2013 Apr
REPOSITORIES: biostudies-literature
Hausser Jean J Syed Afzal Pasha AP Bilen Biter B Zavolan Mihaela M
Genome research 20130118 4
Most of what is presently known about how miRNAs regulate gene expression comes from studies that characterized the regulatory effect of miRNA binding sites located in the 3' untranslated regions (UTR) of mRNAs. In recent years, there has been increasing evidence that miRNAs also bind in the coding region (CDS), but the implication of these interactions remains obscure because they have a smaller impact on mRNA stability compared with miRNA-target interactions that involve 3' UTRs. Here we show ...[more]