Ontology highlight
ABSTRACT:
SUBMITTER: Masuda-Suzukake M
PROVIDER: S-EPMC3613715 | biostudies-literature | 2013 Apr
REPOSITORIES: biostudies-literature
Masuda-Suzukake Masami M Nonaka Takashi T Hosokawa Masato M Oikawa Takayuki T Arai Tetsuaki T Akiyama Haruhiko H Mann David M A DM Hasegawa Masato M
Brain : a journal of neurology 20130306 Pt 4
α-Synuclein is the major component of filamentous inclusions that constitute the defining characteristic of neurodegenerative α-synucleinopathies. However, the molecular mechanisms underlying α-synuclein accumulation and spread are unclear. Here we show that intracerebral injections of sarkosyl-insoluble α-synuclein from brains of patients with dementia with Lewy bodies induced hyperphosphorylated α-synuclein pathology in wild-type mice. Furthermore, injection of fibrils of recombinant human and ...[more]