Ontology highlight
ABSTRACT:
SUBMITTER: Rikin A
PROVIDER: S-EPMC3613857 | biostudies-literature | 2010 Feb
REPOSITORIES: biostudies-literature
Developmental dynamics : an official publication of the American Association of Anatomists 20100201 2
The mga gene encodes a unique transcription factor containing both TBOX and bHLHzip DNA-binding domains. Here we describe the structure, expression pattern, and loss-of-function phenotype for zebrafish mga. The mga gene is conserved with mammalian homologs for both DNA-binding domains. It is expressed maternally, and subsequently in the developing brain, heart, and gut, and its depletion causes morphogenetic defects in each of these organ systems. The heart and gut phenotypes are similar to thos ...[more]