Ontology highlight
ABSTRACT:
SUBMITTER: Woo P
PROVIDER: S-EPMC3613933 | biostudies-literature | 2013 Apr
REPOSITORIES: biostudies-literature
Woo Patricia P Humphries Steve E SE
The Journal of clinical investigation 20130401 4
In 1998, we described a novel polymorphism in the promoter (G>C, rs1800795) of the IL-6 (IL6) gene. The common allele, G, exhibited higher transcriptional activity in gene reporter assays and was associated with higher serum IL-6 levels in a small cohort of healthy subjects. We explored the ethnic distribution of these alleles and found significant differences among people of mixed European descent, Africans, and Gujarati Asians. Disease association was established in a cohort of 92 children of ...[more]