Desmoglein-1, differentiation, and disease.
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ABSTRACT:
SUBMITTER: Hammers CM
PROVIDER: S-EPMC3613937 | biostudies-literature | 2013 Apr
REPOSITORIES: biostudies-literature
Publications
Desmoglein-1, differentiation, and disease.
Hammers Christoph M CM Stanley John R JR
The Journal of clinical investigation 20130325 4
Desmoglein-1 (DSG1), a desmosomal protein, maintains the structure of epidermis through its adhesive function. However, heterozygous mutations in DSG1 in humans result in abnormal differentiation, as does downregulation of DSG1 in human skin organ culture, suggesting that it may have important signaling functions. In this issue of the JCI, Harmon et al. elucidate how the binding of the DSG1 cytoplasmic tail to the scaffolding protein Erbin decreases signaling through the Ras-Raf pathway to promo ...[more]
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