Ontology highlight
ABSTRACT:
SUBMITTER: Wang F
PROVIDER: S-EPMC3614002 | biostudies-literature | 2011 Sep
REPOSITORIES: biostudies-literature
Wang Fei F Whynot Andrew A Tung Matthew M Denic Vladimir V
Molecular cell 20110811 5
Tail-anchored (TA) proteins access the secretory pathway via posttranslational insertion of their C-terminal transmembrane domain into the endoplasmic reticulum (ER). Get3 is an ATPase that delivers TA proteins to the ER by interacting with the Get1-Get2 transmembrane complex, but how Get3's nucleotide cycle drives TA protein insertion remains unclear. Here, we establish that nucleotide binding to Get3 promotes Get3-TA protein complex formation by recruiting Get3 to a chaperone that hands over T ...[more]