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Catalytic Asymmetric Synthesis of Highly Substituted Pyrrolizidines.

ABSTRACT: A catalytic asymmetric double (1,3)-dipolar cycloaddition reaction has been developed. Using a chiral silver catalyst, enantioenriched pyrrolizidines can be prepared in one flask from inexpensive, commercially available starting materials. The pyrrolizidine products contain a variety of substitution patterns and as many as six stereogenic centers.

SUBMITTER: Lim AD 

PROVIDER: S-EPMC3614418 | biostudies-literature | 2012 Nov

REPOSITORIES: biostudies-literature

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Catalytic Asymmetric Synthesis of Highly Substituted Pyrrolizidines.

Lim Andrew D AD   Codelli Julian A JA   Reisman Sarah E SE  

Chemical science 20121101 2

A catalytic asymmetric double (1,3)-dipolar cycloaddition reaction has been developed. Using a chiral silver catalyst, enantioenriched pyrrolizidines can be prepared in one flask from inexpensive, commercially available starting materials. The pyrrolizidine products contain a variety of substitution patterns and as many as six stereogenic centers. ...[more]

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