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Double-ligand modulation for engineering magnetic nanoclusters.


ABSTRACT: Magnetic nanoclusters (MNCs) are agglomerated individual magnetic nanoparticles (MNPs) that show great promise in increasing magnetic resonance imaging (MRI) sensitivity. Here, we report an effective strategy to engineer MNCs based on double-ligand modulation to enhance MRI sensitivity. The oleic acid-coated individual MNPs self-assembled and then were enveloped by polysorbate 80, using a nanoemulsion method to prepare MNCs. By modulating the amounts of the two ligands, and thus the size and magnetic content of the resultant MNCs, we were able to enormously improve MRI sensitivity.

SUBMITTER: Kim B 

PROVIDER: S-EPMC3614429 | biostudies-literature | 2013 Feb

REPOSITORIES: biostudies-literature

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Double-ligand modulation for engineering magnetic nanoclusters.

Kim Bongjune B   Yang Jaemoon J   Lim Eun-Kyung EK   Park Joseph J   Suh Jin-Suck JS   Park Hyo Seon HS   Huh Yong-Min YM   Haam Seungjoo S  

Nanoscale research letters 20130222 1


Magnetic nanoclusters (MNCs) are agglomerated individual magnetic nanoparticles (MNPs) that show great promise in increasing magnetic resonance imaging (MRI) sensitivity. Here, we report an effective strategy to engineer MNCs based on double-ligand modulation to enhance MRI sensitivity. The oleic acid-coated individual MNPs self-assembled and then were enveloped by polysorbate 80, using a nanoemulsion method to prepare MNCs. By modulating the amounts of the two ligands, and thus the size and mag  ...[more]

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