Ontology highlight
ABSTRACT:
SUBMITTER: Chen S
PROVIDER: S-EPMC3614485 | biostudies-literature | 2013 Feb
REPOSITORIES: biostudies-literature
Chen Shan S Xu Qingfu Q Zeng Mingtao M
Vaccine 20130104 7
We have previously shown that an adenovirus vectored vaccine delivered intramuscularly or intranasally was effective in protection against botulism in a mouse model. The adenoviral vector encodes a human codon-optimized heavy chain C-fragment (H(C)50) of botulinum neurotoxin type C (BoNT/C). Here, we evaluate the same vaccine candidate as an oral vaccine against BoNT/C in a mouse model. To elicit protective immunity, the mice were orally vaccinated with a single dose of 1×10(4) to 1×10(7)plaque ...[more]