Ontology highlight
ABSTRACT:
SUBMITTER: Saha MN
PROVIDER: S-EPMC3614876 | biostudies-literature | 2013 Mar
REPOSITORIES: biostudies-literature
Saha Manujendra N MN Qiu Lugui L Chang Hong H
Journal of hematology & oncology 20130327
p53 is a powerful tumor suppressor and is an attractive cancer therapeutic target. A breakthrough in cancer research came from the discovery of the drugs which are capable of reactivating p53 function. Most anti-cancer agents, from traditional chemo- and radiation therapies to more recently developed non-peptide small molecules exert their effects by enhancing the anti-proliferative activities of p53. Small molecules such as nutlin, RITA, and PRIMA-1 that can activate p53 have shown their anti-t ...[more]