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Genome sequence of Staphylococcus lugdunensis N920143 allows identification of putative colonization and virulence factors.

ABSTRACT: Staphylococcus lugdunensis is an opportunistic pathogen related to Staphylococcus aureus and Staphylococcus epidermidis. The genome sequence of S. lugdunensis strain N920143 has been compared with other staphylococci, and genes were identified that could promote survival of S. lugdunensis on human skin and pathogenesis of infections. Staphylococcus lugdunensis lacks virulence factors that characterize S. aureus and harbours a smaller number of genes encoding surface proteins. It is the only staphylococcal species other than S. aureus that possesses a locus encoding iron-regulated surface determinant (Isd) proteins involved in iron acquisition from haemoglobin.

SUBMITTER: Heilbronner S

PROVIDER: S-EPMC3615170 | biostudies-literature | 2011 Sep

REPOSITORIES: biostudies-literature

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Genome sequence of Staphylococcus lugdunensis N920143 allows identification of putative colonization and virulence factors.

Heilbronner Simon S Holden Matthew T G MT van Tonder Andries A Geoghegan Joan A JA Foster Timothy J TJ Parkhill Julian J Bentley Stephen D SD

FEMS microbiology letters 20110704 1

Staphylococcus lugdunensis is an opportunistic pathogen related to Staphylococcus aureus and Staphylococcus epidermidis. The genome sequence of S. lugdunensis strain N920143 has been compared with other staphylococci, and genes were identified that could promote survival of S. lugdunensis on human skin and pathogenesis of infections. Staphylococcus lugdunensis lacks virulence factors that characterize S. aureus and harbours a smaller number of genes encoding surface proteins. It is the only stap ...[more]

PMID: 21682763

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