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Impaired fasting glucose and impaired glucose tolerance have distinct lipoprotein and apolipoprotein changes: the insulin resistance atherosclerosis study.


ABSTRACT:

Context

Cardiovascular risk is increased in individuals with impaired glucose tolerance (IGT) and impaired fasting glucose (IFG); however, those with IGT appear to be at greater risk. Lipoprotein abnormalities occur also in the prediabetic state.

Objective

The authors examined lipoprotein composition in IGT and IFG.

Design and setting

Cross-sectional analysis of a large epidemiological study was done.

Participants

The Insulin Resistance Atherosclerosis Study had a total of 1107 participants.

Main measures

Lipoproteins and apolipoproteins were measured by conventional methods and lipoprotein composition by nuclear magnetic resonance spectroscopy.

Results

Compared with normal glucose tolerance, apolipoprotein B (105.2 vs 99.8 mg/dL, P < .05) was high in isolated IFG, triglyceride (1.48 vs 1.16 mmol/L, P < .001) was high in isolated IGT, and high-density lipoprotein cholesterol was low in combined IFG/IGT (1.12 vs 1.26 mmol/L, P < .001). Nuclear magnetic resonance spectroscopy revealed additional changes: increased total low-density lipoprotein (LDL) particles (1190 vs 1096 nmol/L, P < .01) in isolated IFG; increased large very-low-density lipoprotein (3.61 vs 2.47 nmol/L, P < .01) and small LDL subclass particles (665 vs 541 nmol/L, P < .05) and decreased large LDL subclass particles (447 vs 513 nmol/L, P < .01) in isolated IGT; and decreased large high-density lipoprotein subclass particles in combined IFG/IGT (4.24 vs 5.39 ?mol/L, P < .001).

Conclusions

Isolated IFG is characterized by increased apolipoprotein B and total LDL particles, whereas isolated IGT is associated with increased triglycerides, large very-low-density lipoprotein subclass particles, and structural remodeling of LDL particles. These results may help to explain differences in cardiovascular disease risk in the prediabetic state.

SUBMITTER: Lorenzo C 

PROVIDER: S-EPMC3615208 | biostudies-literature | 2013 Apr

REPOSITORIES: biostudies-literature

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Publications

Impaired fasting glucose and impaired glucose tolerance have distinct lipoprotein and apolipoprotein changes: the insulin resistance atherosclerosis study.

Lorenzo Carlos C   Hartnett Sara S   Hanley Anthony J AJ   Rewers Marian J MJ   Wagenknecht Lynne E LE   Karter Andrew J AJ   Haffner Steven M SM  

The Journal of clinical endocrinology and metabolism 20130228 4


<h4>Context</h4>Cardiovascular risk is increased in individuals with impaired glucose tolerance (IGT) and impaired fasting glucose (IFG); however, those with IGT appear to be at greater risk. Lipoprotein abnormalities occur also in the prediabetic state.<h4>Objective</h4>The authors examined lipoprotein composition in IGT and IFG.<h4>Design and setting</h4>Cross-sectional analysis of a large epidemiological study was done.<h4>Participants</h4>The Insulin Resistance Atherosclerosis Study had a to  ...[more]

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