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ABSTRACT: Context
Cardiovascular risk is increased in individuals with impaired glucose tolerance (IGT) and impaired fasting glucose (IFG); however, those with IGT appear to be at greater risk. Lipoprotein abnormalities occur also in the prediabetic state.Objective
The authors examined lipoprotein composition in IGT and IFG.Design and setting
Cross-sectional analysis of a large epidemiological study was done.Participants
The Insulin Resistance Atherosclerosis Study had a total of 1107 participants.Main measures
Lipoproteins and apolipoproteins were measured by conventional methods and lipoprotein composition by nuclear magnetic resonance spectroscopy.Results
Compared with normal glucose tolerance, apolipoprotein B (105.2 vs 99.8 mg/dL, P < .05) was high in isolated IFG, triglyceride (1.48 vs 1.16 mmol/L, P < .001) was high in isolated IGT, and high-density lipoprotein cholesterol was low in combined IFG/IGT (1.12 vs 1.26 mmol/L, P < .001). Nuclear magnetic resonance spectroscopy revealed additional changes: increased total low-density lipoprotein (LDL) particles (1190 vs 1096 nmol/L, P < .01) in isolated IFG; increased large very-low-density lipoprotein (3.61 vs 2.47 nmol/L, P < .01) and small LDL subclass particles (665 vs 541 nmol/L, P < .05) and decreased large LDL subclass particles (447 vs 513 nmol/L, P < .01) in isolated IGT; and decreased large high-density lipoprotein subclass particles in combined IFG/IGT (4.24 vs 5.39 ?mol/L, P < .001).Conclusions
Isolated IFG is characterized by increased apolipoprotein B and total LDL particles, whereas isolated IGT is associated with increased triglycerides, large very-low-density lipoprotein subclass particles, and structural remodeling of LDL particles. These results may help to explain differences in cardiovascular disease risk in the prediabetic state.
SUBMITTER: Lorenzo C
PROVIDER: S-EPMC3615208 | biostudies-literature | 2013 Apr
REPOSITORIES: biostudies-literature
Lorenzo Carlos C Hartnett Sara S Hanley Anthony J AJ Rewers Marian J MJ Wagenknecht Lynne E LE Karter Andrew J AJ Haffner Steven M SM
The Journal of clinical endocrinology and metabolism 20130228 4
<h4>Context</h4>Cardiovascular risk is increased in individuals with impaired glucose tolerance (IGT) and impaired fasting glucose (IFG); however, those with IGT appear to be at greater risk. Lipoprotein abnormalities occur also in the prediabetic state.<h4>Objective</h4>The authors examined lipoprotein composition in IGT and IFG.<h4>Design and setting</h4>Cross-sectional analysis of a large epidemiological study was done.<h4>Participants</h4>The Insulin Resistance Atherosclerosis Study had a to ...[more]