Ontology highlight
ABSTRACT:
SUBMITTER: Kyutoku M
PROVIDER: S-EPMC3615337 | biostudies-literature | 2013
REPOSITORIES: biostudies-literature
Kyutoku Mariko M Nakagami Hironori H Koriyama Hiroshi H Nakagami Futoshi F Shimamura Munehisa M Kurinami Hitomi H Tomioka Hideki H Miyake Takashi T Katsuya Tomohiro T Morishita Ryuichi R
Scientific reports 20130101
Lipoprotein(a) [Lp(a)] is an unique lipoprotein consisting of the glycoprotein apolipoprotein(a) [apo(a)] in low-density lipoprotein. Although Lp(a) is a well-known independent risk factor for cardiovascular disease; however, there is no drugs to decrease plasma Lp(a) level. Thus, to inhibit the biological activity of Lp(a), we developed DNA vaccine for apo(a) by the targeting to the selected 12 hydrophilic amino acids in the kringle-4 type 2 domain of apo(a). Hepatitis B virus core protein was ...[more]