Genes encoding heterotrimeric G-proteins are associated with gray matter volume variations in the medial frontal cortex.

ABSTRACT: G-protein-coupled signal transduction mediates most cellular responses to hormones and neurotransmitters; this signaling system transduces a large variety of extracellular stimuli into neurons and is the most widely used mechanism for cell communication at the synaptic level. The heterotrimeric G-proteins have been well established as key regulators of neuronal growth, differentiation, and function. More recently, the heterotrimeric G-protein genes group was associated with general cognitive ability. Although heterotrimeric G-proteins are linked to both cognitive ability and neuron signaling, it is unknown whether heterotrimeric G-proteins are also important for brain structure. We tested for association between local cerebral gray matter volume and the heterotrimeric G-protein genes group

SUBMITTER: Chavarria-Siles I 

PROVIDER: S-EPMC3615342 | biostudies-literature | 2013 May

REPOSITORIES: biostudies-literature