Ontology highlight
ABSTRACT:
SUBMITTER: Huang S
PROVIDER: S-EPMC3615419 | biostudies-literature | 2013 Feb
REPOSITORIES: biostudies-literature
Huang Sha S Undisz Andreas A Diez-Silva Monica M Bow Hansen H Dao Ming M Han Jongyoon J
Integrative biology : quantitative biosciences from nano to macro 20130201 2
Artesunate (ART) is widely used for the treatment of malaria, but the mechanisms of its effects on parasitized red blood cells (RBCs) are not fully understood. We investigated ART's influence on the dynamic deformability of ring-stage Plasmodium falciparum infected red blood cells (iRBCs) in order to elucidate its role in cellular mechanobiology. The dynamic deformability of RBCs was measured by passing them through a microfluidic device with repeated bottleneck structures. The quasi-static defo ...[more]