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Chimeric antigen receptor therapy for chronic lymphocytic leukemia: what are the challenges?

ABSTRACT: Chimeric antigen receptor (CAR)-modified T cells targeting CD19 expressed by normal and malignant B cells is a unique therapy for patients with chronic lymphocytic leukemia (CLL); recent results highlight the potential of this therapy for patients with relapsed CLL. Because adoptive transfer of CAR-modified T cells is a novel approach, there are issues for the medical oncologist to consider when evaluating current and future clinical trials for CLL patients. This article reviews the impact of CAR design, T-cell production, T-cell dose, conditioning regimens, and tumor burden at the time of CAR-modified T-cell infusion on the efficacy of this therapy.

SUBMITTER: Davila ML

PROVIDER: S-EPMC3615434 | biostudies-literature | 2013 Apr

REPOSITORIES: biostudies-literature

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Chimeric antigen receptor therapy for chronic lymphocytic leukemia: what are the challenges?

Davila Marco L ML Brentjens Renier R

Hematology/oncology clinics of North America 20130401 2

Chimeric antigen receptor (CAR)-modified T cells targeting CD19 expressed by normal and malignant B cells is a unique therapy for patients with chronic lymphocytic leukemia (CLL); recent results highlight the potential of this therapy for patients with relapsed CLL. Because adoptive transfer of CAR-modified T cells is a novel approach, there are issues for the medical oncologist to consider when evaluating current and future clinical trials for CLL patients. This article reviews the impact of CA ...[more]

PMID: 23561477

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