Ontology highlight
ABSTRACT:
SUBMITTER: Huang W
PROVIDER: S-EPMC3615448 | biostudies-literature | 2013 Apr
REPOSITORIES: biostudies-literature
Huang Wei W Zhu Ping Jun PJ Zhang Shixing S Zhou Hongyi H Stoica Loredana L Galiano Mauricio M Krnjević Krešimir K Roman Gregg G Costa-Mattioli Mauro M
Nature neuroscience 20130303 4
A major goal of biomedical research is the identification of molecular and cellular mechanisms that underlie memory storage. Here we report a previously unknown signaling pathway that is necessary for the conversion from short- to long-term memory. The mammalian target of rapamycin (mTOR) complex 2 (mTORC2), which contains the regulatory protein Rictor (rapamycin-insensitive companion of mTOR), was discovered only recently and little is known about its function. We found that conditional deletio ...[more]