Ontology highlight
ABSTRACT:
SUBMITTER: Sun Z
PROVIDER: S-EPMC3615468 | biostudies-literature | 2013
REPOSITORIES: biostudies-literature
Sun Zhiqi Z Gong Jingyi J Wu Han H Xu Wenyi W Wu Lizhen L Xu Dijin D Gao Jinlan J Wu Jia-Wei JW Yang Hongyuan H Yang Maojun M Li Peng P
Nature communications 20130101
Mature white adipocytes contain a characteristic unilocular lipid droplet. However, the molecular mechanisms underlying unilocular lipid droplet formation are poorly understood. We previously showed that Fsp27, an adipocyte-specific lipid droplet-associated protein, promotes lipid droplet growth by initiating lipid exchange and transfer. Here, we identify Perilipin1 (Plin1), another adipocyte-specific lipid droplet-associated protein, as an Fsp27 activator. Plin1 interacts with the CIDE-N domain ...[more]