Ontology highlight
ABSTRACT:
SUBMITTER: Liu MJ
PROVIDER: S-EPMC3615478 | biostudies-literature | 2013 Feb
REPOSITORIES: biostudies-literature
Liu Ming-Jie MJ Bao Shengying S Gálvez-Peralta Marina M Pyle Charlie J CJ Rudawsky Andrew C AC Pavlovicz Ryan E RE Killilea David W DW Li Chenglong C Nebert Daniel W DW Wewers Mark D MD Knoell Daren L DL
Cell reports 20130209 2
Activation of the transcription factor NF-κB is essential for innate immune function and requires strict regulation. The micronutrient zinc modulates proper host defense, and zinc deficiency is associated with elevated inflammation and worse outcomes in response to bacterial infection and sepsis. Previous studies suggest that zinc may regulate NF-κB activity during innate immune activation, but a mechanistic basis to support this has been lacking. Herein, we report that the zinc transporter SLC3 ...[more]