Ontology highlight
ABSTRACT:
SUBMITTER: Cebollero E
PROVIDER: S-EPMC3615650 | biostudies-literature | 2012 Sep
REPOSITORIES: biostudies-literature
Cebollero Eduardo E van der Vaart Aniek A Zhao Mantong M Rieter Ester E Klionsky Daniel J DJ Helms J Bernd JB Reggiori Fulvio F
Current biology : CB 20120705 17
<h4>Background</h4>The biogenesis of autophagosomes, the hallmark of autophagy, depends on the function of the autophagy-related (Atg) proteins and the generation of phosphatidylinositol-3-phosphate (PtdIns3P) at the phagophore assembly site (PAS), the location where autophagosomes arise. The current model is that PtdIns3P is involved primarily in the recruitment of Atg proteins to the PAS and that once an autophagosome is complete, the Atg machinery is released from its surface back into the cy ...[more]