Ontology highlight
ABSTRACT: Background
Recent genome-wide studies identified a risk locus for colorectal cancer at 18q21, which maps to the SMAD7 gene. Our objective was to confirm the association between SMAD7 SNPs and colorectal cancer risk in the multi-center Colon Cancer Family Registry.Materials and methods
23 tagging SNPs in the SMAD7 gene were genotyped among 1,592 population-based and 253 clinic-based families. The SNP-colorectal cancer associations were assessed in multivariable conditional logistic regression.Results
Among the population-based families, both SNPs rs12953717 (odds ratio, 1.29; 95% confidence interval, 1.12-1.49), and rs11874392 (odds ratio, 0.80; 95% confidence interval, 0.70-0.92) were associated with risk of colorectal cancer. These associations were similar among the population- and the clinic-based families, though they were significant only among the former. Marginally significant differences in the SNP-colorectal cancer associations were observed by use of nonsteroidal anti-inflammatory drugs, cigarette smoking, body mass index, and history of polyps.Conclusions
SMAD7 SNPs were associated with colorectal cancer risk in the Colon Cancer Family Registry. There was evidence suggesting that the association between rs12953717 and colorectal cancer risk may be modified by factors such as smoking and use of nonsteroidal anti-inflammatory drugs.
SUBMITTER: Jiang X
PROVIDER: S-EPMC3616155 | biostudies-literature | 2013
REPOSITORIES: biostudies-literature
Jiang Xuejuan X Castelao J Esteban JE Vandenberg David D Carracedo Angel A Redondo Carmen M CM Conti David V DV Paredes Cotoré Jesus P JP Potter John D JD Newcomb Polly A PA Passarelli Michael N MN Jenkins Mark A MA Hopper John L JL Gallinger Steven S Le Marchand Loic L Martínez María E ME Ahnen Dennis J DJ Baron John A JA Lindor Noralane M NM Haile Robert W RW Gago-Dominguez Manuela M
PloS one 20130403 4
<h4>Background</h4>Recent genome-wide studies identified a risk locus for colorectal cancer at 18q21, which maps to the SMAD7 gene. Our objective was to confirm the association between SMAD7 SNPs and colorectal cancer risk in the multi-center Colon Cancer Family Registry.<h4>Materials and methods</h4>23 tagging SNPs in the SMAD7 gene were genotyped among 1,592 population-based and 253 clinic-based families. The SNP-colorectal cancer associations were assessed in multivariable conditional logisti ...[more]