Interdependence of AMPK and SIRT1 for metabolic adaptation to fasting and exercise in skeletal muscle.
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ABSTRACT:
SUBMITTER: Canto C
PROVIDER: S-EPMC3616265 | biostudies-literature | 2010 Mar
REPOSITORIES: biostudies-literature
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Interdependence of AMPK and SIRT1 for metabolic adaptation to fasting and exercise in skeletal muscle.
Cantó Carles C Jiang Lake Q LQ Deshmukh Atul S AS Mataki Chikage C Coste Agnes A Lagouge Marie M Zierath Juleen R JR Auwerx Johan J
Cell metabolism 20100301 3
During fasting and after exercise, skeletal muscle efficiently switches from carbohydrate to lipid as the main energy source to preserve glycogen stores and blood glucose levels for glucose-dependent tissues. Skeletal muscle cells sense this limitation in glucose availability and transform this information into transcriptional and metabolic adaptations. Here we demonstrate that AMPK acts as the prime initial sensor that translates this information into SIRT1-dependent deacetylation of the transc ...[more]
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