Ontology highlight
ABSTRACT:
SUBMITTER: D'Angiolella V
PROVIDER: S-EPMC3616325 | biostudies-literature | 2012 May
REPOSITORIES: biostudies-literature
Cell 20120501 5
F-box proteins are the substrate binding subunits of SCF (Skp1-Cul1-F-box protein) ubiquitin ligase complexes. Using affinity purifications and mass spectrometry, we identified RRM2 (the ribonucleotide reductase family member 2) as an interactor of the F-box protein cyclin F. Ribonucleotide reductase (RNR) catalyzes the conversion of ribonucleotides to deoxyribonucleotides (dNTPs), which are necessary for both replicative and repair DNA synthesis. We found that, during G2, following CDK-mediated ...[more]