Ontology highlight
ABSTRACT:
SUBMITTER: Mendoza A
PROVIDER: S-EPMC3616498 | biostudies-literature | 2012 Nov
REPOSITORIES: biostudies-literature
Mendoza Alejandra A Bréart Béatrice B Ramos-Perez Willy D WD Pitt Lauren A LA Gobert Michael M Sunkara Manjula M Lafaille Juan J JJ Morris Andrew J AJ Schwab Susan R SR
Cell reports 20121025 5
Plasma sphingosine-1-phosphate (S1P) regulates vascular permeability, and plasma and lymph S1P guide lymphocyte egress from lymphoid organs. S1P is made intracellularly, and little is known about how S1P is delivered into circulatory fluids. Here, we find that mice without the major facilitator superfamily transporter Spns2 have a profound reduction in lymph S1P, but only a minor decrease in plasma S1P. Spns2-deficient mice have a redistribution of lymphocytes from the spleen to lymph nodes and ...[more]