HDAC inhibition suppresses primary immune responses, enhances secondary immune responses, and abrogates autoimmunity during tumor immunotherapy.
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ABSTRACT:
SUBMITTER: Bridle BW
PROVIDER: S-EPMC3616544 | biostudies-literature | 2013 Apr
REPOSITORIES: biostudies-literature
Publications
HDAC inhibition suppresses primary immune responses, enhances secondary immune responses, and abrogates autoimmunity during tumor immunotherapy.
Bridle Byram W BW Chen Lan L Lemay Chantal G CG Diallo Jean-Simon JS Pol Jonathan J Nguyen Andrew A Capretta Alfredo A He Rongqiao R Bramson Jonathan L JL Bell John C JC Lichty Brian D BD Wan Yonghong Y
Molecular therapy : the journal of the American Society of Gene Therapy 20130108 4
Histone deacetylase inhibitors (HDACi) can modulate innate antiviral responses and render tumors more susceptible to oncolytic viruses (OVs); however, their effects on adaptive immunity in this context are largely unknown. Our present study reveals an unexpected property of the HDACi MS-275 that enhances viral vector-induced lymphopenia leading to selective depletion of bystander lymphocytes and regulatory T cells while allowing expansion of antigen-specific secondary responses. Coadministration ...[more]
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