Ontology highlight
ABSTRACT:
SUBMITTER: Shen M
PROVIDER: S-EPMC3616728 | biostudies-literature | 2013 Apr
REPOSITORIES: biostudies-literature
Shen Manli M Bellaousov Stanislav S Hiller Michael M de La Grange Pierre P Creamer Trevor P TP Malina Orit O Sperling Ruth R Mathews David H DH Stoilov Peter P Stamm Stefan S
Nucleic acids research 20130207 6
The serotonin receptor 2C plays a central role in mood and appetite control. It undergoes pre-mRNA editing as well as alternative splicing. The RNA editing suggests that the pre-mRNA forms a stable secondary structure in vivo. To identify substances that promote alternative exons inclusion, we set up a high-throughput screen and identified pyrvinium pamoate as a drug-promoting exon inclusion without editing. Circular dichroism spectroscopy indicates that pyrvinium pamoate binds directly to the p ...[more]