Dataset Information

Reproductive, lifestyle, and anthropometric risk factors for cancer in elderly women.

ABSTRACT: With an increasing elderly population, the United States will experience an increased cancer burden in the coming years. We evaluated associations between anthropometric, lifestyle, and reproductive factors and risk of breast, ovarian, and colorectal cancer in a prospective study of postmenopausal women with a focus on diagnoses occurring among very elderly women (?75 years).For each cancer type, we estimated associations with relevant exposures in 2 age bands (<75 vs. ?75 years of age). During 22 years of follow-up, 322 ovarian, 1,311 colon, 315 rectal, and 2,664 breast cancers occurred among 37,459 postmenopausal women (mean age at baseline 62 years, range 55-71 years).For ovarian cancer, we identified few significant associations in either age band. Colon cancer cases had a higher body mass index and were less likely to report estrogen or aspirin use than non-cases, yet these associations were consistent in both age bands. Few risk factors were identified for rectal cancer in women of 75 years of age or more. For breast cancer, notably different patterns were revealed, with alcohol consumption associated with risk in the younger group and previous hysterectomy associated with risk only in the older group.These analyses suggest some important differences in risk factors for cancer depending on the age at diagnosis.This study suggests that etiologic differences may exist in cancers occurring in the very elderly women. The ongoing demographic shift in the United States provides a strong rationale for studies evaluating cancer etiology in the elderly.

SUBMITTER: Poynter JN

PROVIDER: S-EPMC3617066 | biostudies-literature | 2013 Apr

REPOSITORIES: biostudies-literature

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Reproductive, lifestyle, and anthropometric risk factors for cancer in elderly women.

Poynter Jenny N JN Inoue-Choi Maki M Ross Julie A JA Jacobs David R DR Robien Kimberly K

Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology 20130219 4

<h4>Background</h4>With an increasing elderly population, the United States will experience an increased cancer burden in the coming years. We evaluated associations between anthropometric, lifestyle, and reproductive factors and risk of breast, ovarian, and colorectal cancer in a prospective study of postmenopausal women with a focus on diagnoses occurring among very elderly women (≥75 years).<h4>Methods</h4>For each cancer type, we estimated associations with relevant exposures in 2 age bands ...[more]

PMID: 23429062

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Project description:BackgroundIn the past decades, Greenland has changed from a hunter society to a more western lifestyle, causing less intake of traditional food, such as marine mammals, fish and seabirds. These changes in the living conditions and food habits might impact the maternal health in Greenland.ObjectivesTo describe lifestyle, reproductive factors and food intake in Greenlandic pregnant women, and to assess possible age and geographical differences.DesignCross-sectional study of 189 Greenlandic pregnant women. Inclusion criteria were ?18 years and lived >50% of their life in Greenland. Data were collected in 2010-2011, and information was obtained from lifestyle and food frequency questionnaires. Two age groups for comparison were given for the pregnant women (<27 years vs. ?27 years) with regard to the median age. Region groups for comparison were West, Disko Bay, South, North and East.ResultsPopulation characteristics showed that 43.3% had pre-pregnancy body mass index (BMI) >25.0 kg/m(2), 46.3% were current smokers in the beginning of their pregnancy and few participants consumed alcohol during pregnancy. Women <27 years were more in doubt regarding planned breastfeeding period and consumed more dried fish and fast food. A trend for higher alcohol intake during pregnancy was found for women ?27 years. The regional differences showed that women living >50% in North, South and West had a higher alcohol intake during pregnancy. Women in North had the fewest breastfeeding plans. Women in Disko Bay had the lowest intake of terrestrial species. No significant geographical differences were found for intake of marine mammals or seabirds.ConclusionsThe present study found relatively high BMI level and high smoking frequency in Greenlandic pregnant women. Age and region differences were found for alcohol consumption, breastfeeding plans and food intake profile. Further research is needed to implement relevant maternal health intervention programs in Greenland.

Dataset Information

Reproductive, lifestyle, and anthropometric risk factors for cancer in elderly women.

Publications

Reproductive, lifestyle, and anthropometric risk factors for cancer in elderly women.

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