Ontology highlight
ABSTRACT:
SUBMITTER: Duran J
PROVIDER: S-EPMC3618391 | biostudies-literature | 2013 Apr
REPOSITORIES: biostudies-literature
Duran Jordi J Saez Isabel I Gruart Agnès A Guinovart Joan J JJ Delgado-García José M JM
Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism 20130102 4
Glycogen is the only carbohydrate reserve of the brain, but its overall contribution to brain functions remains unclear. Although it has traditionally been considered as an emergency energetic reservoir, increasing evidence points to a role of glycogen in the normal activity of the brain. To address this long-standing question, we generated a brain-specific Glycogen Synthase knockout (GYS1(Nestin-KO)) mouse and studied the functional consequences of the lack of glycogen in the brain under alert ...[more]