Ontology highlight
ABSTRACT:
SUBMITTER: Bodogai M
PROVIDER: S-EPMC3618504 | biostudies-literature | 2013 Apr
REPOSITORIES: biostudies-literature
Bodogai Monica M Lee Chang Catalina C Wejksza Katarzyna K Lai Jinping J Merino Maria M Wersto Robert P RP Gress Ronald E RE Chan Andrew C AC Hesdorffer Charles C Biragyn Arya A
Cancer research 20130130 7
The possible therapeutic benefits of B-cell depletion in combating tumoral immune escape have been debated. In support of this concept, metastasis of highly aggressive 4T1 breast cancer cells in mice can be abrogated by inactivation of tumor-evoked regulatory B cells (tBreg). Here, we report the unexpected finding that B-cell depletion by CD20 antibody will greatly enhance cancer progression and metastasis. Both murine and human tBregs express low levels of CD20 and, as such, anti-CD20 mostly en ...[more]