Acetyl-coenzyme A synthetase 2 is a nuclear protein required for replicative longevity in Saccharomyces cerevisiae.
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ABSTRACT:
SUBMITTER: Falcon AA
PROVIDER: S-EPMC3618671 | biostudies-literature | 2010 Jan
REPOSITORIES: biostudies-literature
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Acetyl-coenzyme A synthetase 2 is a nuclear protein required for replicative longevity in Saccharomyces cerevisiae.
Falcón Alaric A AA Chen Shaoping S Wood Michael S MS Aris John P JP
Molecular and cellular biochemistry 20090719 1-2
Acs2p is one of two acetyl-coenzyme A synthetases in Saccharomyces cerevisiae. We have prepared and characterized a monoclonal antibody specific for Acs2p and find that Acs2p is localized primarily to the nucleus, including the nucleolus, with a minor amount in the cytosol. We find that Acs2p is required for replicative longevity: an acs2 Delta strain has a reduced replicative life span compared to wild-type and acs1 Delta strains. Furthermore, replicatively aged acs2 Delta cells contain elevate ...[more]
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