Polymeric nanoparticle-based activatable near-infrared nanosensor for protease determination in vivo.
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ABSTRACT:
SUBMITTER: Lee S
PROVIDER: S-EPMC3618996 | biostudies-literature | 2009 Dec
REPOSITORIES: biostudies-literature
Publications
Polymeric nanoparticle-based activatable near-infrared nanosensor for protease determination in vivo.
Lee Seulki S Ryu Ju Hee JH Park Kyeongsoon K Lee Aeju A Lee Seung-Young SY Youn In-Chan IC Ahn Cheol-Hee CH Yoon Soon Man SM Myung Seung-Jae SJ Moon Dae Hyuk DH Chen Xiaoyuan X Choi Kuiwon K Kwon Ick Chan IC Kim Kwangmeyung K
Nano letters 20091201 12
We report here a new protease activatable strategy based on a polymer nanoparticle platform. This nanosensor delivers chemically labeled matrix metalloproteinase (MMP)-activatable fluorogenic peptides to the specific MMPs of interest in vivo. Intravenous administration of the nanosensor in an MMP-positive SCC-7 xenograft tumor and a colon cancer mouse model verified the enzyme specificity of the nanosensor in vivo. The design platform of the nanosensor is flexible and can be fine-tuned for a wid ...[more]
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