Ontology highlight
ABSTRACT:
SUBMITTER: Xie R
PROVIDER: S-EPMC3619036 | biostudies-literature | 2013 Feb
REPOSITORIES: biostudies-literature
Xie Ruiyu R Everett Logan J LJ Lim Hee-Woong HW Patel Nisha A NA Schug Jonathan J Kroon Evert E Kelly Olivia G OG Wang Allen A D'Amour Kevin A KA Robins Allan J AJ Won Kyoung-Jae KJ Kaestner Klaus H KH Sander Maike M
Cell stem cell 20130111 2
Embryonic development is characterized by dynamic changes in gene expression, yet the role of chromatin remodeling in these cellular transitions remains elusive. To address this question, we profiled the transcriptome and select chromatin modifications at defined stages during pancreatic endocrine differentiation of human embryonic stem cells. We identify removal of Polycomb group (PcG)-mediated repression on stage-specific genes as a key mechanism for the induction of developmental regulators. ...[more]