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Fecal microbiota diversity in survivors of adolescent/young adult Hodgkin lymphoma: a study of twins.


ABSTRACT:

Background

Adolescent/young adult Hodgkin lymphoma (AYAHL) survivors report fewer exposures to infections during childhood compared with controls, and they have functional lymphocyte aberrations. The gut microbiota plays a central role in immunity.

Methods

We investigated whether fecal microbial diversity differed between 13 AYAHL survivors and their unaffected co-twin controls. Pyrosequencing of fecal bacterial 16S rRNA amplicons yielded 252?943 edited reads that were assigned to species-level operational taxonomic units (OTUs) and standardised for sequencing depth by random sampling. Microbial diversity was compared within vs between twin pairs and by case-control status.

Results

The number of unique OTUs was more similar within twin pairs compared with randomly paired participants (P=0.0004). The AYAHL cases had fewer unique OTUs compared with their co-twin controls (338 vs 369, P=0.015); this difference was not significant (169 vs 183, P=0.10) when restricted to abundant OTUs.

Conclusion

In this small study, AYAHL survivors appear to have a deficit of rare gut microbes. Further work is needed to determine if reduced microbial diversity is a consequence of the disease, its treatment, or a particularly hygienic environment.

SUBMITTER: Cozen W 

PROVIDER: S-EPMC3619077 | biostudies-literature | 2013 Mar

REPOSITORIES: biostudies-literature

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Fecal microbiota diversity in survivors of adolescent/young adult Hodgkin lymphoma: a study of twins.

Cozen W W   Yu G G   Gail M H MH   Ridaura V K VK   Nathwani B N BN   Hwang A E AE   Hamilton A S AS   Mack T M TM   Gordon J I JI   Goedert J J JJ  

British journal of cancer 20130226 5


<h4>Background</h4>Adolescent/young adult Hodgkin lymphoma (AYAHL) survivors report fewer exposures to infections during childhood compared with controls, and they have functional lymphocyte aberrations. The gut microbiota plays a central role in immunity.<h4>Methods</h4>We investigated whether fecal microbial diversity differed between 13 AYAHL survivors and their unaffected co-twin controls. Pyrosequencing of fecal bacterial 16S rRNA amplicons yielded 252 943 edited reads that were assigned to  ...[more]

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