Ontology highlight
ABSTRACT:
SUBMITTER: Lorenz-Fonfria VA
PROVIDER: S-EPMC3619329 | biostudies-literature | 2013 Apr
REPOSITORIES: biostudies-literature
Lórenz-Fonfría Víctor A VA Resler Tom T Krause Nils N Nack Melanie M Gossing Michael M Fischer von Mollard Gabriele G Bamann Christian C Bamberg Ernst E Schlesinger Ramona R Heberle Joachim J
Proceedings of the National Academy of Sciences of the United States of America 20130318 14
The discovery of the light-gated ion channel channelrhodopsin (ChR) set the stage for the novel field of optogenetics, where cellular processes are controlled by light. However, the underlying molecular mechanism of light-induced cation permeation in ChR2 remains unknown. Here, we have traced the structural changes of ChR2 by time-resolved FTIR spectroscopy, complemented by functional electrophysiological measurements. We have resolved the vibrational changes associated with the open states of t ...[more]