Ontology highlight
ABSTRACT:
SUBMITTER: Nam YJ
PROVIDER: S-EPMC3619357 | biostudies-literature | 2013 Apr
REPOSITORIES: biostudies-literature
Nam Young-Jae YJ Song Kunhua K Luo Xiang X Daniel Edward E Lambeth Kaleb K West Katherine K Hill Joseph A JA DiMaio J Michael JM Baker Linda A LA Bassel-Duby Rhonda R Olson Eric N EN
Proceedings of the National Academy of Sciences of the United States of America 20130304 14
Reprogramming of mouse fibroblasts toward a myocardial cell fate by forced expression of cardiac transcription factors or microRNAs has recently been demonstrated. The potential clinical applicability of these findings is based on the minimal regenerative potential of the adult human heart and the limited availability of human heart tissue. An initial but mandatory step toward clinical application of this approach is to establish conditions for conversion of adult human fibroblasts to a cardiac ...[more]